Current Views on the Problem of Antibiotic Resistance and its Negotia-tion in Clinical Pediatrics
It is known that resistance to antibiotics has always existed. So far, no antibiotic, effective to all pathogenic bacteria, have been created (and probably will never be).
Resistance of microorganisms to antibiotics can be intrinsic and acquired. The intrinsic (spontaneous) stability is characterized by absence in microorganisms of action target of antibiotic or inaccessibility of target owing to initially low permeability or an enzymatic inactivation. When bacteria have natural stability, antibiotics are clinically inefficient.